Product Overview
BMS-906024 | T14680 | TargetMol Chemicals
CAS: 1401066-79-2
Smiles: CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C1=O)c1ccccc1
Formula: C26H26F6N4O3
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: BMS-906024 is an oral and selective gamma secretase inhibitor (GSI) that is a small molecule Notch inhibitor[1]. BMS-906024 demonstrates broad-spectrum antineoplastic activity against a wide array of human cancer xenografts[2]. BMS-906024 prevents the activation of all four Notch receptors with a high oral bioavailability with IC50s of 1.6, 0.7, 3.4, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively.
Molecular Weight: 556, 509
