Product Overview
BMS202 hydrochloride (1675203-84-5(free base)) | T4696 | TargetMol Chemicals
CAS: T4696
Smiles: Cl.COc1nc(OCc2cccc(c2C)-c2ccccc2)ccc1CNCCNC(C)=O
Formula: C25H30ClN3O3
Pathway: Apoptosis|||Cell Cycle/Checkpoint|||Immunology/Inflammation
Target: PD-1/PD-L1
Receptor: N/A
Bioactivity: PD-1/PD-L1 inhibitor 2 is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM). Biophysical studies demonstrate that BMS202 binds directly to PD-L1. Binding of BMS202 promotes PD-L1 dimerisation and blocks the PD-L1/ PD1 interaction.
Molecular Weight: 455, 97
