Product Overview
Boehmenan | TN3525 | TargetMol Chemicals
CAS: 57296-22-7
Smiles: COc1cc(CCCOC(=O)\C=C\c2ccc(O)c(OC)c2)cc2[C@@H](COC(=O)\C=C\c3ccc(O)c(OC)c3)[C@@H](Oc12)c1ccc(O)c(OC)c1
Formula: C40H40O12
Pathway: Angiogenesis|||Apoptosis|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||DNA Damage/DNA Repair|||JAK/STAT signaling|||MAPK|||Metabolism|||PI3K/Akt/mTOR signaling|||Proteases/Proteasome|||Stem Cells|||Tyrosine Kinase/Adaptors
Target: ERK|||Phosphatase|||EGFR|||PARP|||MEK|||Wnt/beta-catenin|||Akt|||Caspase|||STAT|||p53
Receptor: N/A
Bioactivity: (±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotoxic effects against many cancer cell lines, boehmenan-mediated anti-tumor property is mediated by modulation of mitochondria and EGFR signaling pathway in A549 NSCLC cells.
Molecular Weight: 712, 8
