Product Overview
Bosentan | T6264 | TargetMol Chemicals
CAS: 147536-97-8
Smiles: COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCO)-c1ncccn1
Formula: C27H29N5O6S
Pathway: GPCR/G Protein
Target: Endothelin Receptor
Receptor: N/A
Bioactivity: Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension.
Molecular Weight: 551, 62
