Product Overview
Bragsin2 | T14775 | TargetMol Chemicals
CAS: 342795-08-8
Smiles: COc1ccc2oc(cc(=O)c2c1[N+]([O-])=O)C(F)(F)F
Formula: C11H6F3NO5
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: Bragsin2 is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of Afr guanine nucleotide exchange factor BRAG2 that inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin2 binds at the interface between the pleckstrin homology domain of BRAG2 and the lipid bilayer, leading BRAG2 unable to activate lipidated Arf GTPase.
Molecular Weight: 289, 166