Product Overview
BRD6989 | T14778 | TargetMol Chemicals
CAS: 642008-81-9
Smiles: CC1CCc2nc(N)c(C#N)c(-c3cccnc3)c2C1
Formula: C16H16N4
Pathway: Cell Cycle/Checkpoint|||Immunology/Inflammation
Target: IL Receptor|||CDK|||Interleukin
Receptor: N/A
Bioactivity: BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM.
Molecular Weight: 264, 332