Product Overview
Brevilin A | T4672 | TargetMol Chemicals
CAS: 16503-32-5
Smiles: C/C=C(C)\C(O[C@H]1[C@@]([C@@H]2C)([H])[C@@](OC2=O)([H])C[C@@H](C)[C@@]3([H])[C@]1(C(C=C3)=O)C)=O
Formula: C20H26O5
Pathway: Angiogenesis|||Apoptosis|||Autophagy|||Chromatin/Epigenetic|||JAK/STAT signaling|||Microbiology/Virology|||Stem Cells
Target: Apoptosis|||Anti-infection|||JAK|||STAT|||Autophagy
Receptor: N/A
Bioactivity: Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 μM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumour
Molecular Weight: 346, 41