Brevilin A | T4672

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€301.00 - €592.00
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TMC-T4672
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Product Overview

Brevilin A | T4672 | TargetMol Chemicals

CAS: 16503-32-5

Smiles: C/C=C(C)\C(O[C@H]1[C@@]([C@@H]2C)([H])[C@@](OC2=O)([H])C[C@@H](C)[C@@]3([H])[C@]1(C(C=C3)=O)C)=O

Formula: C20H26O5

Pathway: Angiogenesis|||Apoptosis|||Autophagy|||Chromatin/Epigenetic|||JAK/STAT signaling|||Microbiology/Virology|||Stem Cells

Target: Apoptosis|||Anti-infection|||JAK|||STAT|||Autophagy

Receptor: N/A

Bioactivity: Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 μM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumour

Molecular Weight: 346, 41

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