Product Overview
Broussonin A | TN3539 | TargetMol Chemicals
CAS: 73731-87-0
Smiles: COc1ccc(CCCc2ccc(O)cc2)c(O)c1
Formula: C16H18O3
Pathway: Cytoskeletal Signaling|||Immunology/Inflammation|||MAPK|||NF-Κb|||PI3K/Akt/mTOR signaling
Target: ERK|||IL Receptor|||IκB/IKK|||NOS|||NF-κB|||Akt
Receptor: N/A
Bioactivity: Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A can significantly inhibit adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay; it suppresses lipopolysaccharide (LPS)-stimulated inducible nitric oxide synthase (iNOS) expression at the transcriptional level through modulating NF-κB and down-regulation of the Akt and ERK signaling pathways.
Molecular Weight: 258, 32
