Product Overview
BSJ-4-116 | T9117 | TargetMol Chemicals
CAS: 2519823-34-6
Smiles: O=C(NCCCCCCCN1C[C@H](NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(C(C)C)=O)=N2)CCC1)COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O
Formula: C40H49ClN8O8S
Pathway: Cell Cycle/Checkpoint
Target: CDK
Receptor: N/A
Bioactivity: BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation).
Molecular Weight: 837, 38
