Product Overview
BT2 | T14834 | TargetMol Chemicals
CAS: 34576-94-8
Smiles: OC(=O)c1sc2cc(Cl)ccc2c1Cl
Formula: C9H4Cl2O2S
Pathway: Apoptosis
Target: BCL
Receptor: N/A
Bioactivity: BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC).
Molecular Weight: 247, 09