Product Overview
BTRX-335140 | T14835 | TargetMol Chemicals
CAS: 2244614-14-8
Smiles: CCc1cc(F)c2nc(N3CCC(CC3)NC3CCOCC3)c(-c3nc(C)no3)c(C)c2c1
Formula: C25H32FN5O2
Pathway: Endocrinology/Hormones|||GPCR/G Protein|||Neuroscience
Target: Opioid Receptor
Receptor: N/A
Bioactivity: BTRX-335140 is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively. BTRX-335140 can distribute well into the CNS. ADMET (absorption, distribution, metabolism, excretion, and toxicity) . BTRX-335140 endows with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rats.
Molecular Weight: 453, 562