Product Overview
Buclizine dihydrochloride | T6426 | TargetMol Chemicals
CAS: 129-74-8
Smiles: Cl.Cl.CC(C)(C)c1ccc(CN2CCN(CC2)C(c2ccccc2)c2ccc(Cl)cc2)cc1
Formula: C28H35Cl3N2
Pathway: GPCR/G Protein|||Immunology/Inflammation|||Neuroscience
Target: 5-HT Receptor|||AChR|||Histamine Receptor
Receptor: N/A
Bioactivity: Buclizine HCl is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine binds to and blocks the histamine H1 receptor, thereby preventing the symptoms that are caused by histamine activity. Buclizine exerts its anti-emetic effect by binding to and blocking the muscarinic and histamine receptors in the vomiting center of the central nervous system (CNS). This may prevent activation of the chemoreceptor trigger zone (CTZ) and may reduce nausea and vomiting.
Molecular Weight: 505, 95
