Butyrolactone 3 | T14839

Butyrolactone 3 | T14839 | TargetMol Chemicals

CAS: 778649-18-6

Smiles: CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O

Formula: C9H12O4

Pathway: Others

Target: Others

Receptor: N/A

Bioactivity: Butyrolactone 3 is a specifical inhibitor of the histone acetyltransferase Gcn5 (IC50: 100 μM) with a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50: 0.5 mM).

Molecular Weight: 184, 191