Product Overview
BX795 | T1830 | TargetMol Chemicals
CAS: 702675-74-9
Smiles: Ic1cnc(Nc2cccc(NC(=O)N3CCCC3)c2)nc1NCCCNC(=O)c1cccs1
Formula: C23H26IN7O2S
Pathway: Autophagy|||Cell Cycle/Checkpoint|||NF-Κb|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors
Target: IκB/IKK|||Chk|||CDK|||c-Kit|||PDK|||Autophagy
Receptor: N/A
Bioactivity: BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respectively. Meanwhile, the selectivity for PDK1 is 100-fold than GSK3β.
Molecular Weight: 591, 47
