Product Overview
C188 | T26936 | TargetMol Chemicals
CAS: 823828-18-8
Smiles: OC(=O)CSc1cc(NS(=O)(=O)c2ccc(cc2)C(O)=O)c2ccccc2c1O
Formula: C19H15NO7S2
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: C188 is a cell-permeable naphthol compound and a STAT3 inhibitor. C188 inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket, while exhibiting little effect against IFN-γ-stimulated HepG2 cellular STAT1 phosphorylation.
Molecular Weight: 433, 45
