Product Overview
Caffeic Acid Phenethyl Ester | T6429 | TargetMol Chemicals
CAS: 104594-70-9
Smiles: Oc1ccc(\C=C\C(=O)OCCc2ccccc2)cc1O
Formula: C17H16O4
Pathway: Apoptosis|||NF-Κb
Target: Apoptosis|||NF-κB
Receptor: N/A
Bioactivity: Caffeic Acid Phenethyl Ester (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective and immunomodulating activities. CAPE is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1).
Molecular Weight: 284, 311
