Product Overview
Cambinol | T4019 | TargetMol Chemicals
CAS: 14513-15-6
Smiles: O=c1c(Cc2c3ccccc3ccc2O)c(c2ccccc2)[nH]c(=S)[nH]1
Formula: C21H16N2O2S
Pathway: Apoptosis|||Chromatin/Epigenetic|||DNA Damage/DNA Repair|||Metabolism
Target: Apoptosis|||Phospholipase|||Sirtuin
Receptor: N/A
Bioactivity: Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and no inhibitory for the class I and II HDACs. In BCL6-expressing Burkitt lymphoma cell lines, Cambinol-induced apoptosis has been attributed to the hyperacetylation of p53 and BCL6.Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)
Molecular Weight: 360, 09
