Product Overview
Capecitabine | T1408 | TargetMol Chemicals
CAS: 154361-50-9
Smiles: CCCCCOC(=O)Nc1nc(=O)n(cc1F)[C@@H]1O[C@H](C)[C@@H](O)[C@H]1O
Formula: C15H22FN3O6
Pathway: Apoptosis|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Target: Apoptosis|||Nucleoside Antimetabolite/Analog|||DNA/RNA Synthesis
Receptor: N/A
Bioactivity: Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.
Molecular Weight: 359, 354
