Product Overview
Capillarisin | TN3587 | TargetMol Chemicals
CAS: 56365-38-9
Smiles: COc1c(O)cc2oc(Oc3ccc(O)cc3)cc(=O)c2c1O
Formula: C16H12O7
Pathway: Angiogenesis|||Apoptosis|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||GPCR/G Protein|||Immunology/Inflammation|||JAK/STAT signaling|||MAPK|||Neuroscience|||NF-Κb|||Proteases/Proteasome|||Stem Cells|||Tyrosine Kinase/Adaptors
Target: MMP|||ERK|||IL Receptor|||BCL|||VEGFR|||TNF|||NOS|||NF-κB|||TLR|||MAPK|||COX|||DNA/RNA Synthesis|||Prostaglandin Receptor|||JNK|||STAT
Receptor: N/A
Bioactivity: Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with G0/G1-phase cell cycle arrest and loss in mitochondrial membrane potential.Capillarisin has anti-inflammatory activity, can inhibit LPS-induced inflammation by blocking TLR4-mediated NF-κB and MAPKs activation in BV2 microglia. Capillarisin possesses promising anti-hyperalgesic and anti-allodynic effects through the inhibition of various inflammatory pain signaling.
Molecular Weight: 316, 26