Product Overview
Capmatinib 2HCl | T4260 | TargetMol Chemicals
CAS: 1197376-85-4
Smiles: Cl.Cl.CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Formula: C23H19Cl2FN6O
Pathway: Tyrosine Kinase/Adaptors
Target: c-Met/HGFR
Receptor: N/A
Bioactivity: INCB-28060(free base) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, INCB 28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.
Molecular Weight: 485, 34
