Product Overview
CAY10602 | T4062 | TargetMol Chemicals
CAS: 374922-43-7
Smiles: Nc1c(c2nc3ccccc3nc2n1-c1ccc(F)cc1)S(=O)(=O)c1ccccc1
Formula: C22H15FN4O2S
Pathway: Chromatin/Epigenetic|||DNA Damage/DNA Repair
Target: Sirtuin
Receptor: N/A
Bioactivity: CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells, with approximately 75% inhibition achieved at 60 μM, without cytotoxicity.
Molecular Weight: 418, 45