Product Overview
CBL0137 | T4126 | TargetMol Chemicals
CAS: 1197996-80-7
Smiles: CC(C)NCCn1c2ccc(cc2c2cc(ccc12)C(C)=O)C(C)=O
Formula: C21H24N2O2
Pathway: Apoptosis|||NF-Κb
Target: NF-κB|||p53
Receptor: N/A
Bioactivity: CBL0137, a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preClinicalal models of pancreatic cancer.
Molecular Weight: 336, 435
