Product Overview
CBR-5884 | T14884 | TargetMol Chemicals
CAS: 681159-27-3
Smiles: CCOC(=O)c1sc(NC(=O)c2ccco2)c(SC#N)c1C
Formula: C14H12N2O4S2
Pathway: Metabolism|||Others
Target: Others|||Dehydrogenase
Receptor: N/A
Bioactivity: CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH
Molecular Weight: 336, 38
