Product Overview
CCT128930 hydrochloride | T6303L | TargetMol Chemicals
CAS: 2453324-32-6
Smiles: Cl.NC1(Cc2ccc(Cl)cc2)CCN(CC1)c1ncnc2[nH]ccc12
Formula: C18H21Cl2N5
Pathway: Apoptosis|||Autophagy|||Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||Akt|||PKA|||mTOR|||Autophagy
Receptor: N/A
Bioactivity: CCT128930 hydrochloride is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28-fold selectivity over the closely related PKA kinase (IC50: 168 nM) through the targeting of Met282 of AKT, as well as 20-fold selectivity over p70S6K (IC50: 120 nM).
Molecular Weight: 378, 3
