Product Overview
Cediranib | T2500 | TargetMol Chemicals
CAS: 288383-20-0
Smiles: COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1
Formula: C25H27FN4O3
Pathway: Angiogenesis|||Autophagy|||Tyrosine Kinase/Adaptors
Target: VEGFR|||FLT|||PDGFR|||c-Kit|||Autophagy
Receptor: N/A
Bioactivity: Cediranib (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/≤3 nM), similar activity against PDGFRβ and c-Kit, selective more for VEGFR than PDGFR-α (36-fold), CSF-1R (110-fold), and Flt3 (1000-fold) in HUVEC cells.
Molecular Weight: 450, 514
