Product Overview
Ceritinib dihydrochloride | T1791L | TargetMol Chemicals
CAS: 1380575-43-8
Smiles: Cl.Cl.CC(C)Oc1cc(C2CCNCC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1
Formula: C28H38Cl3N5O3S
Pathway: Angiogenesis|||Tyrosine Kinase/Adaptors
Target: IGF-1R|||ALK
Receptor: N/A
Bioactivity: Ceritinib dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, InsR, and STK22D (IC50 values of 8, 7, and 23 nM, respectively), shows great antitumor potency
Molecular Weight: 631, 05
