Product Overview
CH5447240 | T25234 | TargetMol Chemicals
CAS: 1253919-92-4
Smiles: C[C@H]1CC[C@@H](CC1)C1=NC2(CCN(CC2)S(=O)(=O)CCc2c(C)cc(cc2C)N(C)C(N)=O)C(=O)N1
Formula: C26H39N5O4S
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: CH5447240 is an effective Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist for the treatment of Hypoparathyroidism. CH5447240 showed a potent in vitro hPTHR1 agonist effect (EC20: 3.0 nM; EC50: 12 nM). It showed 55% oral bioavailability and a significantly elevated serum calcium level in hypocalcemic model rats.
Molecular Weight: 517, 69