Product Overview
CHDI-390576 | T14947 | TargetMol Chemicals
CAS: 1629729-98-1
Smiles: ONC(=O)C(c1ccc(cc1)-c1ncc(cn1)C(F)(F)F)c1ccccc1F
Formula: C19H13F4N3O2
Pathway: Chromatin/Epigenetic|||DNA Damage/DNA Repair
Target: HDAC
Receptor: N/A
Bioactivity: CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform.
Molecular Weight: 391, 326