Product Overview
CIL56 | T4309 | TargetMol Chemicals
CAS: 300802-28-2
Smiles: ON=C1c2cc(ccc2-c2ccc(cc12)S(=O)(=O)N1CCCCC1)S(=O)(=O)N1CCCCC1
Formula: C23H27N3O5S2
Pathway: Apoptosis|||Cell Cycle/Checkpoint|||Immunology/Inflammation
Target: Ferroptosis|||ROS
Receptor: N/A
Bioactivity: CIL56 is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in HT-1080 cells in vitro.HT-1080 cells lacking acetyl-CoA carboxylase 1 (ACC1), the rate-limiting enzyme in fatty acid synthesis, exhibit 5-fold resistance to CIL56 treatment, indicating ACC1 activity sensitizes cells to CIL56-induced cell death.
Molecular Weight: 489, 61