Product Overview
Cilastatin | T2583 | TargetMol Chemicals
CAS: 82009-34-5
Smiles: S(C[C@H](N)C(=O)O)CCCC/C=C(\NC(=O)[C@@H]1C(C1)(C)C)/C(=O)O
Formula: C16H26N2O5S
Pathway: Microbiology/Virology|||Proteases/Proteasome|||Ubiquitination
Target: Proteasome|||Antibacterial|||Antibiotic
Receptor: N/A
Bioactivity: Cilastatin is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
Molecular Weight: 358, 45
