Product Overview
CK59 | T27032 | TargetMol Chemicals
CAS: 926319-75-7
Smiles: CC(C)n1cnc2c(NCCCCCCNC(=O)OC(C)(C)C)nc(NCCO)nc12
Formula: C21H37N7O3
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: CK59 is a reversible inhibitor of calcium-calmodulin-dependent kinase II (CaMKII). CK59 inhibits multiple voltage-gated calcium channels, including the L-type channel during depolarization in a dose-dependent manner. The IC50 for CK59 was approximately 50 μM, which is only five fold larger than the reported IC50 values for CaMKII inhibition.
Molecular Weight: 435, 573