Product Overview
CL2 Linker | T17730 | TargetMol Chemicals
CAS: 2270986-66-6
Smiles: CN(CCN(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCn2cc(CNC(=O)CCCCCN3C(=O)C=CC3=O)nn2)cc1)C(=O)OCC(=O)CO
Formula: C68H103N11O22
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours)[1][2].
Molecular Weight: 1426, 627
