CL2A-SN-38 DCA 1279680-68-0(free base) | T17731L

(No reviews yet) Write a Review
€287.00 - €2,673.00
SKU:
TMC-T17731L
Availability:
IN STOCK
Adding to cart… The item has been added

Product Overview

CL2A-SN-38 DCA 1279680-68-0(free base) | T17731L | TargetMol Chemicals

CAS: T17731L

Smiles: OC(=O)C(Cl)Cl.OC(=O)C(Cl)Cl.CCc1c2Cn3c(cc4c(COC(=O)[C@@]4(CC)OC(=O)OCc4ccc(NC(=O)[C@H](CCCCN)NC(=O)COCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCn5cc(CNC(=O)C6CCC(CN7C(=O)C=CC7=O)CC6)nn5)cc4)c3=O)-c2nc2ccc(O)cc12

Formula: C77H101Cl4N11O26

Pathway: Others

Target: Others

Receptor: N/A

Bioactivity: CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC).. CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a noncleavable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. .

Molecular Weight: 1738, 49

Reviews

(No reviews yet) Write a Review