Product Overview
CMPD101 | T14989 | TargetMol Chemicals
CAS: 865608-11-3
Smiles: Cn1c(CNc2cccc(c2)C(=O)NCc2ccccc2C(F)(F)F)nnc1-c1ccncc1
Formula: C24H21F3N6O
Pathway: Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||GPCR/G Protein|||Stem Cells
Target: ROCK|||GRK|||PKC
Receptor: N/A
Bioactivity: CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with IC50s of 3.1 μM, 2.3 μM, 1.4 μM and 8.1 μM, respectively.
Molecular Weight: 466, 468