Product Overview
Cobimetinib | T3623 | TargetMol Chemicals
CAS: 934660-93-2
Smiles: OC1(CN(C1)C(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F)[C@@H]1CCCCN1
Formula: C21H21F3IN3O2
Pathway: Apoptosis|||MAPK
Target: Apoptosis|||MEK
Receptor: N/A
Bioactivity: Cobimetinib is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) (IC50: 0.9 nM). Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation.
Molecular Weight: 531, 318
