Product Overview
Copanlisib dihydrochloride | T14998 | TargetMol Chemicals
CAS: 1402152-13-9
Smiles: Cl.Cl.COc1c(OCCCN2CCOCC2)ccc2C3=NCCN3C(NC(=O)c3cnc(N)nc3)=Nc12
Formula: C23H30Cl2N8O4
Pathway: Apoptosis|||PI3K/Akt/mTOR signaling
Target: Apoptosis|||PI3K|||mTOR
Receptor: N/A
Bioactivity: Copanlisib dihydrochloride is an ATP-competitive pan-class I PI3K inhibitor (IC50s: 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ). Copanlisib dihydrochloride has superior antitumor activity and it also has more than 2, 000-fold selectivity against other lipid and protein kinases, except for mTOR.
Molecular Weight: 553, 45
