Product Overview
Coptisine | T5S0053 | TargetMol Chemicals
CAS: 3486-66-6
Smiles: C1Oc2cc3CC[n+]4cc5c6OCOc6ccc5cc4-c3cc2O1
Formula: C19H14NO4
Pathway: Metabolism
Target: Indoleamine 2, 3-Dioxygenase (IDO)
Receptor: N/A
Bioactivity: 1. Coptisine treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial apoptosis and inflammation by inhibiting the Rho/ROCK pathway. 3. Coptisine is a potential anti-osteosarcoma drug candidate, via exerting a strong anti-osteosarcoma effect with very low toxicity . 4. Coptisine with a high dosage could inhibit cholesterol synthesis via suppressing the HMGCR expression and promoting the use and excretion of cholesterol via up-regulating LDLR and CYP7A1 expression. 5. Coptisine suppresses adhesion, migration and invasion of MDA-MB-231 breast cancer cells in vitro, the down-regulation of MMP-9 in combination with the increase of TIMP-1 possibly contributing to the anti-metastatic function for breast cancer.
Molecular Weight: 320, 323
