Product Overview
Cutamesine dihydrochloride | T3597 | TargetMol Chemicals
CAS: 165377-44-6
Smiles: Cl.Cl.COc1ccc(CCN2CCN(CCCc3ccccc3)CC2)cc1OC
Formula: C23H34Cl2N2O2
Pathway: GPCR/G Protein
Target: Sigma receptor
Receptor: N/A
Bioactivity: Cutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. In a rat model of experimental stroke, it enhances brain plasticity and sensorimotor function.
Molecular Weight: 441, 44
