Product Overview
CYC-116 | T6458 | TargetMol Chemicals
CAS: 693228-63-6
Smiles: Cc1nc(N)sc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Formula: C18H20N6OS
Pathway: Angiogenesis|||Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||MAPK|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors
Target: VEGFR|||FLT|||CDK|||S6 Kinase|||Aurora Kinase
Receptor: N/A
Bioactivity: CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.
Molecular Weight: 368, 46
