[D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P acetate | TP1931L1

[D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P acetate | TP1931L1 | TargetMol Chemicals

CAS: TP1931L1

Smiles: CC(C)C[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CC3=CC=CC=C3)NC([C@@H](CC4=CNC5=C4C=CC=C5)NC([C@H](CCC(N)=O)NC([C@@H](CC6=CC=CC=C6)NC([C@H]7N(C([C@H](CCCCN)NC([C@H]8N(C([C@@H](CCCNC(N)=N)N)=O)CCC8)=O)=O)CCC7)=O)=O)=O)=O)=O)=O)=O.CC(O)=O

Formula: C81H113N19O14

Pathway: GPCR/G Protein

Target: cholecystokinin

Receptor: N/A

Bioactivity: Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces apoptosis and inhibits cancer cell growth in vitro.

Molecular Weight: 1576, 91