Product Overview
Danicopan | T8509 | TargetMol Chemicals
CAS: 1903768-17-1
Smiles: CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccc(cc12)-c1cnc(C)nc1
Formula: C26H23BrFN7O3
Pathway: Immunology/Inflammation
Target: Complement System
Receptor: N/A
Bioactivity: Danicopan (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the complement replacement pathway (APC) and may block the complement replacement pathway in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
Molecular Weight: 580, 418