Product Overview
Dbet57 | T5440 | TargetMol Chemicals
CAS: 1883863-52-2
Smiles: Cc1nnc2[C@H](CC(=O)NCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
Formula: C34H31ClN8O5S
Pathway: Chromatin/Epigenetic
Target: Epigenetic Reader Domain
Receptor: N/A
Bioactivity: dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM, and inactive on BRD4BD2
Molecular Weight: 699, 18