Product Overview
Dehydroglyasperin C | TN3806 | TargetMol Chemicals
CAS: 199331-35-6
Smiles: COc1c(CC=C(C)C)c(O)cc2OCC(=Cc12)c1ccc(O)cc1O
Formula: C21H22O5
Pathway: Apoptosis|||Autophagy|||Cell Cycle/Checkpoint|||Cytoskeletal Signaling|||DNA Damage/DNA Repair|||Immunology/Inflammation|||MAPK|||Metabolism|||Neuroscience|||NF-Κb|||PI3K/Akt/mTOR signaling
Target: ERK|||IκB/IKK|||p38 MAPK|||TNF|||NF-κB|||Akt|||COX|||PI3K|||NADPH|||DNA/RNA Synthesis|||Nrf2|||JNK|||Autophagy
Receptor: N/A
Bioactivity: Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protective effects against chronic diseases caused by reactive oxygen species as well as potential as an antioxidant food additive. Dehydroglyasperin C protects neuronal cells against glutamate-induced oxidative injury through the induction of HO-1 expression, which is, in turn, activated maybe through Nrf2-Keap1 and PI3K/AKT signaling pathways.
Molecular Weight: 354, 4
