Product Overview
(-)-Denudatin B | TN3831 | TargetMol Chemicals
CAS: 87402-88-8
Smiles: COc1ccc(cc1OC)[C@H]1OC2=CC(=O)C(CC=C)=C[C@]2(OC)[C@@H]1C
Formula: C21H24O5
Pathway: GPCR/G Protein|||Membrane transporter/Ion channel|||Metabolism
Target: ATPase|||Potassium Channel|||Calcium Channel|||PAFR
Receptor: N/A
Bioactivity: Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, it inhibits the aggregation and ATP release of washed rabbit platelets caused by platelet-activating factor (PAF) in a concentration-dependent manner. Denudatin B relaxes vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels; its effect to increase cGMP may enhance the vasorelaxation. Denudatin B also shows potent 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging activity.
Molecular Weight: 356, 42
