Product Overview
Desmethylanethol trithione | T3560 | TargetMol Chemicals
CAS: 18274-81-2
Smiles: Oc1ccc(cc1)-c1cc(=S)ss1
Formula: C9H6OS3
Pathway: Angiogenesis|||Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors
Target: VEGFR|||Akt
Receptor: N/A
Bioactivity: ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, ADT-OH markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, ADT-OH improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following the stroke.
Molecular Weight: 226, 33
