Product Overview
Deucravacitinib | T14687 | TargetMol Chemicals
CAS: 1609392-27-9
Smiles: [2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC
Formula: C20H22N8O3
Pathway: Angiogenesis|||Chromatin/Epigenetic|||Immunology/Inflammation|||JAK/STAT signaling|||Stem Cells|||Tyrosine Kinase/Adaptors
Target: Tyrosine Kinases|||JAK|||IFNAR|||Interleukin
Receptor: N/A
Bioactivity: BMS-986165 inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain.
Molecular Weight: 425, 467