Product Overview
DK419 | T15137 | TargetMol Chemicals
CAS: 2102672-22-8
Smiles: FC(F)(F)c1nc2cc(Cl)cc(C(=O)Nc3ccc(cc3)C(F)(F)F)c2[nH]1
Formula: C16H8ClF6N3O
Pathway: Cytoskeletal Signaling|||Stem Cells
Target: Wnt/beta-catenin
Receptor: N/A
Bioactivity: DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.
Molecular Weight: 407, 7