Product Overview
DM1-SMe | T21408 | TargetMol Chemicals
CAS: 138148-68-2
Smiles: CO[C@@H]1\C=C/C=C(C)/Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@@H](OC(=O)[C@H](C)N(C)C(=O)CCSSC)[C@]2(C)OC2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2
Formula: C36H50ClN3O10S2
Pathway: Cytoskeletal Signaling
Target: Microtubule Associated
Receptor: N/A
Bioactivity: DM1-SMe is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines.
Molecular Weight: 784, 38
