Product Overview
DM4-SPDP | T17834 | TargetMol Chemicals
CAS: 2245698-48-8
Smiles: CO[C@@H]1C=CC=C(C)Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(=O)[C@H](C)N(C)C(=O)CCC(C)(C)SSCCC(=O)ON2C(=O)CCC2=O)[C@]2(C)O[C@H]2[C@H](C)C2C[C@@]1(O)NC(=O)O2
Formula: C45H61ClN4O14S2
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: DM4-SPDP is a drug-linker conjugate composed of a potent antitubulin agent DM4 and a linker SMCC to make antibody drug conjugate[1]. SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls[2][3].
Molecular Weight: 981, 57
