Product Overview
Dolastatin 10 trifluoroacetate | T22631 | TargetMol Chemicals
CAS: T22631
Smiles: CC[C@]([C@@](N(C([C@](/N=C(O)/[C@](N(C)C)([H])C(C)C)([H])C(C)C)=O)C)([H])[C@@](OC)([H])CC(N1CCC[C@@]1([H])[C@@](OC)([H])[C@@](/C(O)=N/[C@@](C2=NC=CS2)([H])CC3=CC=CC=C3)([H])C)=O)([H])C.FC(F)(C(O)=O)F
Formula: C44H69F3N6O8S
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerization (IC50: 1.2 μM). Besides that, it potently inhibits vincristine binding to tubulin (Ki: 1.4 μM in a non-competitive manner). Dolastatin 10 also shows a moderate effect on enhancing the binding of colchicines to tubulin. In addition, Dolastatin 10 has the inhibitory activity in tubulin-dependent GTP binding.
Molecular Weight: 899, 11
